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NAD⁺ injections before and after: what those photos can and cannot tell you

Before-and-after galleries show one person, chosen by the seller, with nothing controlled. Here is what a photo can actually establish — and the outcomes that were measured when researchers ran real trials instead.

Miriam Hollis6 min read
What a before/after can and cannot establishCAN SHOW· One person changed· They say NAD⁺ was involved· The seller chose this photoCANNOT SHOW· That NAD⁺ caused it· What else changed· The people it didn't work forA photo is one outcome from a sample of one, selected by the person selling you the product.

If you searched for NAD⁺ before-and-after pictures, you were probably hoping to see whether this works before spending a few hundred dollars on it. That is an entirely sensible thing to want. We are not going to show you a gallery, and the reason is the most useful thing on this page.

What a before/after photo actually establishes

One person changed between two photographs, and the company selling the product chose to publish that pair.

That is the complete list. It does not establish that NAD⁺ caused the change, because nothing controlled for what else happened in those weeks — sleep, training, diet, a new job, a GLP-1 prescription, the ordinary motivation that comes from spending money on your health. It does not show you the people for whom nothing happened, because those pairs do not get published. And it cannot separate the product from the placebo effect, which in a category sold on subjective feelings like energy and focus is not a small consideration.

This is not cynicism about NAD⁺ specifically. It is what a testimonial is worth in any category, and it is exactly why controlled trials exist.

What was measured, when somebody measured it

Here is the substitute for a gallery — the outcomes that have actually been recorded in randomized human trials, which is a much shorter list than the marketing implies and includes at least one result the marketing never mentions.

Blood NAD⁺ rises. In a randomized, double-blind, placebo-controlled trial of 80 healthy middle-aged adults (n = 80), blood NAD rose significantly in every NMN dose group at day 30 and day 60 against placebo and baseline (all p ≤ 0.001) [1]. Real, repeatable, and a blood marker rather than anything you would photograph.

Some metabolic markers moved. In overweight or obese middle-aged and older adults, an NMN formulation significantly reduced total LDL cholesterol, non-HDL cholesterol, body weight and diastolic blood pressure [2]. Genuine findings, in a specific population, on a lab report rather than in a mirror.

And cognition did not. In a placebo-controlled randomized trial in older adults with mild cognitive impairment, NR did not alter cognition — the placebo group’s scores improved across the study, consistent with a practice effect, while the NR group’s did not change [3]. You will not find that outcome in anybody’s before-and-after gallery.

What this means for the thing you were about to buy

Every trial above used an oral precursor. The injections and IV drips those galleries belong to have no controlled outcome trials at all — so for the exact product being marketed with the photos, the measured evidence is not thin, it is absent.

If you want to try NAD⁺ anyway, that is a reasonable personal decision, and the honest way to make it is on price and logistics rather than on transformations. Start with an oral precursor, which costs roughly a quarter of an injection and has the data. If you have decided on an injection, our injections ranking compares the providers on what they actually disclose.

And whatever you choose, decide in advance what you are measuring and when you will check. “Do I feel better?” three weeks into a purchase you wanted to work is the least reliable instrument in this whole category — which is, again, why trials use clamps and blood panels instead of photographs.

Frequently asked

Do NAD⁺ before and after photos prove it works?
No. A before/after pair establishes that one person changed and that the seller chose to publish that pair. It cannot show that NAD⁺ caused the change, because nothing controlled for sleep, diet, training or the ordinary motivation of having spent money, and it cannot show you the people for whom nothing happened.
What results have actually been measured?
In randomized trials of oral precursors: blood NAD⁺ rises reliably, and an NMN formulation reduced LDL and non-HDL cholesterol, body weight and diastolic blood pressure in overweight and obese adults. In the trial that measured cognition in older adults with mild cognitive impairment, NR did not alter it. All of those used oral precursors — injections and IV have no controlled outcome trials.
How long until I see results from NAD⁺?
For the outcome with the best evidence — raised blood NAD⁺ — trials have measured changes within about 30 days of daily oral dosing. For the outcomes people actually hope for, like visible energy or appearance changes, there is no controlled trial establishing that they occur at all, so there is no honest timeline to give you.
Should I take my own before and after photos?
If it helps you, sure, but decide in advance what you are measuring and when you will check, and prefer something less flattering to your own expectations than a photo — a lab panel, a sleep log, a repeatable performance test. Asking yourself 'do I feel better?' a few weeks into a purchase you wanted to work is the least reliable instrument in this category.

Sources

  1. [1] Yi L, Maier AB, Tao R, et al. (2023). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial GeroScience. PMID 36482258
  2. [2] Pencina KM, Valderrabano R, Wipper B, et al. (2023). Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study The Journal of Clinical Endocrinology & Metabolism. PMID 36740954
  3. [3] Orr ME, Kotkowski E, Ramirez P, et al. (2024). A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment GeroScience. PMID 37994989

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